Preheat oven to 350°F. Spritz a 9 x 5 inch loaf pan with baking spray or butter and flour. Set aside.
In a small mixing bowl using an electric mixer, beat together cream cheese, sugar, egg, flour and vanilla until well blended. Set aside.
In a separate bowl, using a whisk, sift together flour, pumpkin pie spice, cinnamon, baking soda and salt.
In a medium-size bowl, using the mixer, beat together, pumpkin, granulated sugar, brown sugar, eggs, oil, sour cream and vanilla until well blended.
Add wet ingredients to dry ingredients mixing until fully combined. Pour one half into the prepared pan.
Dollop cream cheese mixture over batter and gently spread maintaining at least a 1/2 inch border of batter along the edge. Top with remaining batter.
Bake for 60-70 minutes or until a toothpick inserted into the bread portion comes back clean.
Cool in pan for 10 minutes then remove and cool completely on a cooling rack.
Store leftovers chilled.