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Pepperoni Pizza Chicken

This ooey gooey Pepperoni Pizza Chicken is made with chicken breasts coated with an Italian blend of seasonings and parmesan cheese. It’s topped with pepperoni slices and a generous drizzle of pizza sauce then a heaping helping of mozzarella cheese seals the deal. Serve on sub rolls, over pasta or as a lower carb entrée with a side salad any night of the week.

Pepperoni Pizza Chicken

Pepperoni Pizza Chicken

When it comes to quick and easy, boneless skinless chicken breasts can be a busy mom’s best friend. My family never tires of chicken in any form, and it’s served quite often in my Southern style kitchen. Whether it’s a classic dish like chicken fried chicken and peppered milk gravy, or a quick clean-up sweet chili chicken and vegetable foil packs or easy barbecue bacon wrapped chicken breasts I can count on chicken being gobbled up in a hurry by my boys. This variation made with pizza sauce and pepperoni suits everyone’s taste, and I love that it can be made in one skillet. While it bakes, cook your favorite spaghetti or pasta and make a salad and garlic bread to round out the meal.

step-by-step image and ingredients to prepare pizza chicken

Tips for Making Pizza Flavored Chicken

When it comes to chicken, the possibilities are endless. I wanted to mention a few helpful hints for making pepperoni pizza chicken:

  • I use a cast iron skillet to prepare this chicken because it can go from the stovetop to the oven. You can use any oven safe skillet in a similar size. Alternatively, you can also brown the chicken on the stovetop and place into a baking dish to finish in the oven.
  • Chicken breast pieces naturally vary in thickness from end to end. While this recipe doesn’t call for you to flatten the chicken breasts, I do find it helpful to pound the thickest end for the most even cooking. Use the flat side of the meat tenderizer so as not to tear the chicken.
  • Prepared pizza sauces vary in thickness from brand to brand. Use a quality brand for the best results.
  • To thicken the sauce at the end of cooking, carefully remove chicken breasts to a platter and keep warm. Add tomato paste 1 Tbsp at a time to the sauce stirring until melted. Repeat until the sauce has thickened to your taste.
  • While I give a specific number of pepperoni slices in the recipe, you can certainly use more or less, if you like. The number in the recipe should be used as a guideline.
  • If you’re feeling creative, add any of your favorite pizza toppings to this dish to add a variety in flavor. Ingredients such as sauteed peppers, mushrooms and onion or sprinkle the top with sliced black olives.

Pepperoni Pizza Chicken in a Cast Iron Skillet

Other Pizza Inspired Dishes to Enjoy

Pizza is always a hit at our house. Regardless of the flavor combination, it’s a sure fire hit. If you’d like to get the whole family involved, checkout my recipe for no-fail Pizza Dough and host a pizza making party. For a fun twist, add Buffalo Chicken Pizza from Cookies and Cups and Chicken Ranch Pizza from Sargento to your game day menu.

Pepperoni Pizza Chicken

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Pepperoni Pizza Chicken Recipe
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5 from 1 vote

Pepperoni Pizza Chicken

Prep Time15 minutes
Cook Time25 minutes
Resting time5 minutes
Total Time45 minutes
Course: Chicken, Main Course
Cuisine: American
Keyword: chicken-breasts, pepperoni-pizza-chicken
Servings: 4 servings
Calories: 478kcal
Author: Melissa Sperka


  • Olive oil
  • 4 8 oz boneless skinless chicken breasts
  • 1/2 cup grated Parmesan cheese, plus 1 Tbsp divided
  • 1 tsp dry Italian seasoning
  • 1 tsp granulated garlic
  • 1 tsp crushed red pepper flakes
  • 35 slices pepperoni
  • 1 16 oz jar pizza sauce
  • 2 cups shredded mozzarella cheese
  • fresh chopped chives or fresh basil for garnishing
  • tomato paste optional


  • Preheat the oven to 375°F.
  • Pound the chicken breasts to even thickness, if needed. Season lightly with salt and black pepper.
  • On a plate mix together 1/2 cup Parmesan, Italian seasoning, garlic and red pepper flakes. Coat chicken pieces on all sides, repeating until all is used.
  • On the stovetop heat a few drizzles of olive oil in a large 12-inch cast iron skillet or similar oven safe skillet over medium-high heat. Brown the chicken for 2 minutes per side. Remove from stovetop.
  • Pour pizza sauce over chicken. Top each with 3-4 pieces of pepperoni.
  • Sprinkle with mozzarella cheese and remaining Parmesan. Arrange remaining pepperoni on top. (May use more pepperoni, if desired)
  • Bake for 20-25 minutes or until chicken is cooked through and cheese is bubbly.
  • Rest for 5 minutes and serve with pasta or on toasted hoagie rolls.


  • To thicken the sauce at the end of cooking, carefully remove chicken breasts to a platter and keep warm. Add tomato paste 1 Tbsp at a time to the sauce stirring until melted. Repeat until the sauce has thickened to your taste.


Serving: 1serving | Calories: 478kcal | Carbohydrates: 133g | Protein: 72g | Fat: 28g | Saturated Fat: 14g | Polyunsaturated Fat: 1g | Monounsaturated Fat: 8g | Trans Fat: 1g | Cholesterol: 74mg | Sodium: 1007mg | Potassium: 133mg | Fiber: 1g | Sugar: 1g | Vitamin A: 645IU | Vitamin C: 1mg | Calcium: 436mg | Iron: 1mg
Tried this recipe?Mention @melissassk or tag #melissassk!


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